王会，教授、博士生导师，现任职于徐州医科大学江苏省免疫与代谢重点实验室。2005年本科毕业于南京大学生物科学系；2008年获得南京大学医学院硕士学位；2012年获得瑞典哥德堡大学医学科学博士学位；2013年瑞典林雪平大学博士后；2014-2018年美国安德森肿瘤中心免疫系博士后。研究关注1）淋巴细胞分化与自身免疫性疾病；2）小胶质细胞与神经退行性病变。先后主持瑞典国际博士后基金、国家自然科学基金青年和面上项目等。已发表SCI研究论文51篇，近三年以（共同）通讯/最后作者在Cell Rep Med、Genome Med、Theranostics、Frontier Immunol、Immunology 等SCI杂志发表论文12篇。论文被引用1500余次，H指数25。参译出版英文学术专著1部。已指导硕士研究生16名和博士生研究生2名。

 

主持项目及人才称号

·         2022.01 - 2025.12，国家自然科学基金面上基金 （82171791），54万，主持

·         2019.01 - 2021.12，国家自然科学基金青年基金 （31800750），26万，主持

·         2019.01-2021.12，徐州医科大学校级青年创新团队，20万，主持

·         2018.12，徐州市金龙湖紧缺型高层次人才，50万，主持

·         2018.07-2021.06，徐州医科大学优秀人才启动基金，50万，主持

·         2017.10-2020.09， 江苏特聘教授，200万，主持，结题

 

研究文章（#共同贡献）

2024年

1.     Sch?fer S, Smelik M, Sysoev O, Zhao Y, Eklund D, Lilja S, Gustafsson M, Heyn H, Julia A, Kovács IA, Loscalzo J, Marsal S, Zhang H, Li X, Gawel D, Wang H#, Benson M#. scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases. Genome Med, 2024. 16(1):42.

2.     Ren J, Liu K, Hu L, Yang R, Liu Y, Wang S, Chen X, Zhao S, Jing L, Liu T, Hu B, Zhang X, Wang H#, Li H#. An Efficient Probe-Based Quantitative PCR Assay Targeting Human-Specific DNA in ST6GALNAC3 for the Quantification of Human Cells in Preclinical Animal Models. Mol Biotechnol, 2024.

 

2023年

3.     Xu M, Ren J, Jia W, Wang S, Liu Y, Chen X, Shi J#, Wang H#. Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b. Scand J Immunol, 2023:e13309.

4.     Liu K, Hu L, Wang S, Chen X, Liu Y, Zhao S, Wang H, Li L,Li H. An efficient qPCR assay for the quantification of human cells in preclinical animal models by targeting human specific DNA in the intron of BRCA1. Mol Biol Rep, 2023. 50(11):9229-9237.

5.     Lilja S, Li X, Smelik M, Lee EJ, Loscalzo J, Marthanda PB, Hu L, Magnusson M, Sysoev O, Zhang H, Zhao Y, Sjowall C, Gawel D, Wang H#, Benson M#. Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases. Cell Rep Med, 2023. 4(3):100956.

6.     Gao S, Shi Y, Bai R, Li H, Ren J, Chen X, Hu L, Shi Z, Zhao S, Wang H. Sputum basophils from allergic asthmatic patients do not express IL-7Rα that is essential for TSLP signalling. Scand J Immunol, 2023. 97(1):e13236.

 

2022年

7.     Li X, Lee EJ, Lilja S, Loscalzo J, Schafer S, Smelik M, Strobl MR, Sysoev O, Wang H, Zhang H, Zhao Y, Gawel DR, Bohle B, Benson M. A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets. Genome Med, 2022. 14(1):48.

8.     Li H, Tang Y, Ren J, Bai R, Hu L, Jia W, Cao Y, Hong L, Xu M, Gao S, Shi Y, Pan S, Wang L, Zheng K#, Zhao S#, Wang H#. Identification of novel B-1 transitional progenitors by B-1 lymphocyte fate-mapping transgenic mouse model Bhlhe41dTomato-Cre. Front Immunol, 2022. 15:13:946202

9.     He C, Gao S, Zhao X, Shi Y, Tang Y, Cao Y, Bai R, Ren J, Zhao S, Shi Z, Wang H. An efficient and cost-effective method for the purification of human basophils. Cytometry A, 2022. 101(2):150-158.

10. Chen X, Hu J, Wang Y, Lee Y, Zhao X, Lu H, Zhu G, Wang H, Jiang Y, Liu F, Chen Y, Kim BS, Zhou Q, Liu X, Wang X, Chang SH,Dong C. The FoxO4/DKK3 axis represses IFN-gamma expression by Th1 cells and limits antimicrobial immunity. J Clin Invest, 2022. 132(18).

11. Bai RX, Chen XZ, Ren JF, Hu L, Li H, Wang H#, He C#. Toxoplasma gondii rhoptry protein (TgROP18) enhances the expression of pro-inflammatory factor in LPS/IFN-gamma-induced murine BV2 microglia cells via NF-kappaB signal pathway. Acta Trop, 2022. 235:106650.

 

2021年

12. Xie X, Zhu L, Jie Z, Li Y, Gu M, Zhou X, Wang H, Chang JH, Ko CJ, Cheng X,Sun SC. TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells. Cell Mol Immunol, 2021. 18(9):2262-2274.

13. Sun L, Zhao X, Liu X, Zhong B, Tang H, Jin W, Clevers H, Wang H, Wang X,Dong C. Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription. Cell Rep, 2021. 35(9):109188.

14. Shi Y, Xu M, Pan S, Gao S, Ren J, Bai R, Li H, He C, Zhao S, Shi Z, Yu F, Xiang Z, Wang H. Induction of the apoptosis, degranulation and IL-13 production of human basophils by butyrate and propionate via suppression of histone deacetylation. Immunology, 2021. 164(2):292-304.

15. Jie Z, Ko CJ, Wang H, Xie X, Li Y, Gu M, Zhu L, Yang JY, Gao T, Ru W, Tang SJ, Cheng X,Sun SC. Microglia promote autoimmune inflammation via the noncanonical NF-kappaB pathway. Sci Adv, 2021. 7(36):eabh0609.

16. Chen X, Wang C, Sun N, Pan S, Li R, Li X, Zhao J, Tong H, Tang Y, Han J, Qiao J, Qiu H, Wang H#, Yang J#,Ikezoe T#. Aurka loss in CD19⁺ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production. Theranostics, 2021. 11(10):4655-4671.

 

2020年

17. Zhao S, Tang Y, Hong L, Xu M, Pan S, Zhen K, Tang R, Zhai #X, Shi Z#, Wang H#. Interleukin 2 regulates the activation of human basophils. Cytokine, 2020. 127:154934.

18. Hong L, Tang Y, Pan S, Xu M, Shi Y, Gao S, Sui C, He C, Zheng K, Tang R, Shi Z, Wang Q#, Wang H#. Interleukin 3-induced GITR promotes the activation of human basophils. Cytokine, 2020. 136:155268.

19. He C, Xu MZ, Pan S, Wang H, Peng HJ,Liu ZZ. iTRAQ-Based Phosphoproteomic Analysis of Toxoplasma gondii Tachyzoites Provides Insight Into the Role of Phosphorylation for its Invasion and Egress. Front Cell Infect Microbiol, 2020. 10:586466.

20. Han J, Jiang Z, Wang C, Chen X, Li R, Sun N, Liu X, Wang H, Hong L, Zheng K, Yang J, Ikezoe T. Inhibition of Aurora-A Promotes CD8⁺ T-Cell Infiltration by Mediating IL10 Production in Cancer Cells. Mol Cancer Res, 2020. 18(10):1589-1602

 

综述文章

1.     石言彪, 高偲佳, 王会. 短链脂肪酸调控过敏性疾病研究进展[J]. 四川大学学报（医学版）, 2022, 53(1): 28-34.