陈碧
专业型博导
职称:主任医师
***
学院:第一临床医学院
chenbi207@126.com
个人简介

主任医师、教授、博士生导师

徐州医科大学内科学(呼吸系病)学科带头人

中国医师协会呼吸医师分会委员

中国研究型医院学会呼吸病学专业委员会委员

中国医师协会呼吸医师分会间质性肺病工作委员会委员

中国研究型医院学会呼吸病学专业委员会间质性肺疾病多学科诊疗诊治专家委员会委员

江苏省医学会呼吸病学分会委员

江苏省医师协会呼吸医师分会常委

江苏省医师协会内科医师分会常委

江苏省医学会呼吸病学分会肺间质病学组成员

江苏省医师协会呼吸医师分会间质性肺疾病学组副组长

江苏省医学会变态反应学分会青年委员会副主任委员

徐州市医学会呼吸病专业委员会候任主任委员

淮海间质性肺疾病专科联盟负责人 

全国间质性肺疾病规范诊疗中心建设评审专家

      2016年博士毕业于上海交通大学,硕士和博士研究方向均为间质性肺疾病,2018年赴德国埃森大学鲁尔肺科医院研修间质性肺病和呼吸内镜诊疗技术,率先在徐州地区开设间质性肺疾病专病门诊,牵头成立淮海经济区间质性肺疾病专科联盟,建成省内一流、国内具有知名度的间质性肺疾病诊疗中心。

     先后主持国家自然科学基金项目、江苏省卫健委科研项目、徐州市科技项目、江苏省青年医学人才项目和江苏省六大人才高峰高层次人才资助项目等课题10余项,获徐州市医学新技术引进奖3项和实用新型专利1项。以第一/通讯作者发表论文40余篇,其中SCI收录26篇。参编著作3部,作为学组专家参与制定5部有关间质性肺疾病的中国专家共识。获得江苏省科教强卫工程“青年医学重点人才”、江苏省333高层次人才培养对象和江苏省第十五批次“六大人才高峰”高层次人才称号。



 

成果奖励(近五年)

1.基于新型血清标志物的慢性气道疾病诊疗路径优化策略,徐州市医学新技术引进奖,二等奖,2022

2.肺癌分子标志物和微生物菌群的临床应用,徐州市医学新技术引进奖,二等奖,2021

3.阻塞性睡眠呼吸暂停综合征血清炎性标志物的临床应用研究,徐州市医学新技术引进奖,三等奖,2020

4.瘦素在支气管哮喘中的作用机制和临床研究,徐州市政府,科学技术进步奖,三等奖,2016 

5.脂联素对肥胖哮喘大鼠气道炎症和重构的影响,徐州市政府,科学技术进步奖,三等奖,2013 


 

科研项目(近五年)

 

1.  间质性肺疾病急性加重的早期预警体系构建和潜在治疗靶点探索,LCZX202411,徐州医科大学附属医院临床研究专项,面上项目,2024.08-2026.08, 20万元,在研,主持

2. 江苏省卫健委医学科研面上项目(H2023005),基于多组学技术筛选间质性肺病急性加重血浆生物标志物及机制研究,2024.01.01-2026.12.31,5万元,主持

3.呼吸道感染对间质性肺疾病急性加重的影响和机制研究,XWRCHT20220063,徐州市医学重点人才项目,2023年1月-2027年12月,40万元,在研,主持

4.江苏省高校重点实验室开放课题,间质性肺疾病急性加重新型生物标志物的研究,XZSYSKF2022004,2023年1月-2024年12月,2万元,在研,主持

5.基于宏基因组分析和诊断技术的重症肺部感染精准诊疗策略研究,KC21237,徐州市科技项目,5万元,2021/09-2023/08,在研,主持

6.  徐州医科大学附属医院发展基金面上项目,FXR调控肺泡上皮细胞衰老参与肺纤维化的机制研究,XYFM2021004,2021年-2023年,在研,主持

7.徐州医科大学附属医院优秀中青年人才项目,法尼酯X受体FXR调控肺泡上皮细胞衰老参与肺纤维化的机制研究,2020-2023 年,10万元,在研,主持

8. 国家自然科学基金青年科学基金项目,81600044,FXR调控EMT和肺成纤维细胞活化参与肺纤维化的机制研究,2017/01-2019/12,18万元,结题,主持

9.国家自然科学基金重大研究计划培育项目,91629104,法尼酯X受体FXR介导炎性微环境-肿瘤交互作用促进肺癌发生发展研究,2017/01- 2018/12,94万元,结题,主要参与者

10.江苏省青年医学人才项目,QNRC2016798,FXR参与肺纤维化的机制研究,2016/01-2020/12,25万元,结题,主持

11.江苏省“六大人才高峰”高层次人才项目,WSN-081,FXR抑制剂抗肺纤维化的作用与机制研究,2018/11 -2021/11,4万元,在研,主持

12.基质蛋白Periostin参与OSAHS所致气道重塑的机制和临床研究,KC18058,徐州市科技项目,5万元,2018/08-2020/07,结题,共同主持


 

论文情况(近五年)

(1)     Chen B#, Xi B#, Xin H#, Zou R#, Tian Y, Zhao Q, Yan X, Qiu X, Gao Y, Liu Y, Cao M, Jiang H*, He P*, Chen J*, Cai H*. External validation of the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathies in anti-MDA5 antibody-positive interstitial lung disease patients: A multicenter retrospective cohort study in China. Semin Arthritis Rheum. 2025 Feb 27;72:152700. doi: 10.1016/j.

(2)     Xin H#, He P#, Xi B#, Wang Z, Wang H, Wang F, Ma Z, Xue J, Jia Y, Cai H*, Chen B*, Chen J*. Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study. BMC Pulm Med. 2025 Jan 25;25(1):40.

(3)     Pan C#,Wei H#,, Chen B#, Wu L, Song J, Zhang Q, Wu X, Liang G, Chen W*, Wang Y*, Xie Y*. Inhalation of itraconazole mitigates bleomycin-induced lung fibrosis via regulating SPP1 and C3 signaling pathway pivotal in the interaction between phagocytic macrophages and diseased fibroblasts. J Transl Med. 2024 Nov 25;22(1):1058.

(4)     Hu B#, Han Y#,Zhang W#, Zhang Q, Gu W, Bi J*, Chen B*, Xiao L*. A prediction approach to COVID-19 time series with LSTM integrated attention mechanism and transfer learning. BMC Med Res Methodol. 2024 Dec 31;24(1):323.

(5)     Yong Chen#, Pan Zhang#, Zongmei Dong, Yanan Zhu, Yanan Liu, Cheng Qiao, Ning Zhang, Yixue Jiang, Bi Chen*. Effect of Baduanjin exercise on health and functional status in patients with chronic obstructive pulmonary disease: a community-based, cluster-randomized controlled trial. NPJ Prim Care Respir Med. 2024 Dec 19;34(1):43

(6)     Yaqiong Tian, Ping He, Lijun Ren, Hongxia Xin, Bin Xi, Ruyi Zou, Qi Zhao, Xin Yan, Xiaohua Qiu, Yujuan Gao, Yin Liu, Min Cao, Hanyi Jiang*, Bi Chen*, Juan Chen* , Hourong Cai*. Dynamic change of lymphocytes associated with short-term prognosis in anti-MDA5-positive dermatomyositis with interstitial lung disease: a multicenter retrospective study. Clin Rheumatol, 2024 Nov;43(11):3399-3408.

(7)     Zhang P, Zhu Y, Wang Y, Zhang W, Qiao C, Lou H, Liu Y, Dong D, Zhu X, Chen B*. Effects of the teach-back method on the health status of patients with chronic obstructive pulmonary disease: a real-world community-based cluster-randomized controlled trial. J Thorac Dis 2024;16(8):5209-5221

(8)     Guo B#, Liu W#, Ji X#, Xi B#, Meng X, Xie W, Sun Y, Zhang M, Liu P, Zhang W, Yan X*, Chen B*. CSF3 aggravates acute exacerbation of pulmonary fibrosis by disrupting alveolar epithelial barrier integrity. Int Immunopharmacol. 2024 May 23;135:112322.

(9)     Chen Cheng#, Zhifeng Wang#, Chao Ding#, Pingli Liu, Xiaoqiang Xu, Yan Li, Yi Yan, Xiaocong Yin, Bi Chen*, Bing Gu*. Bronchoalveolar Lavage Fluid Microbiota is Associated with the Diagnosis and Prognosis Evaluation of Lung Cancer. Phenomics. 2024 May 4;4(2):125-137.

(10)   Haiyan Qu#, Mengjing Zhu#, Chuxiao Shan#, Xuan Ji, Guijuan Ji, Wenhui Zhang, Hao Zhang*, Bi Chen*. Prevalence, diagnosis, and treatment of chronic obstructive pulmonary disease in a hospitalized lung cancer population: a single center study. J Thorac Dis. 2023 Aug 31;15(8):4182-4197  

(11)   Zhang H, Wang Y, Lou H, Zhu Y, Dong Z, Dong D, Chen P, Zhu X, Chen B*, Zhang P*. Prevalence of and factors associated with alexithymia among patients with chronic obstructive pulmonary disease in China: a cross-sectional study. BMC Pulm Med. 2023 Jan 30;23(1):40.

(12)   Pan Zhang#, Bi Chen#, Heqing Lou, Yanan Zhu, Peipei Chen, Zongmei Dong, Xuan Zhu, Ting Li and Peian Lou*, Predictors and outcomes of obstructive sleep apnea in patients with chronic obstructive pulmonary disease in China: a cross-sectional study. BMC Pulmonary Medicine, 2022, 22:16 

(13)   Bi Chen#, Ya-Nan Liu#, Lei Ji#, Ping-Li Liu, Jun He, Yu-Ying Gan, Gui-Juan Ji, Shu-Yang Zhu, Wen-Hui Zhang*, Elevated levels of interleukin-35 and interleukin-37 in adult patients with obstructive sleep apnea. J Clin Lab Anal. 2021 Jun;35(6):e23790.

(14)   Hong T, Sun T, Zhang M, Liu X, Yuan Y, Dolo PR, Chen B*, Zhang H*. Surgical perspective in neoadjuvant chemoimmunotherapy for stage II-III non-small cell lung cancer. Thoracic Cancer. 2021 Oct;12(20):2796-2802. 

(15)   Chen Cheng#, Zhifeng Wang#, Jingqiao Wang#, Chao Ding , Chuang Sun, Pingli Liu, Xiaoqiang Xu, Yanan Liu, Bi Chen* , Bing Gu*.Characterization of the lung microbiome and exploration of potential bacterial biomarkers for lung cancer. Transl Lung Cancer Res. 2020;9(3):693-704.

(16)   Lei Ji#, Yanan Liu#, Pingli Liu , Guijuan Ji, Jun He, Yuying Gan , Shuyang Zhu, Bi Chen* , Wenhui Zhang*. Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Breath. 2021 Mar;25(1):331-337.

(17)   Yanan Liu#, Chu Wang#, Hao Chen , Maowei Zhang , Jiechen Zhu,  Xiaojiao Zhang , Lei Ji , Shuyang Zhu , Wenhui Zhang* , Bi Chen*. The profibrotic effects of chronic microaspiration of bile acids on lungs of rats at different stages. Int Immunopharmacol. 2020;84:106545.

(18)   He Du # , Bi Chen # , Nan-Lin Jiao , Yan-Hua Liu , San-Yuan Sun, You-Wei Zhang. Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma. Oxid Med Cell Longev. 2020;2020:7370157.

(19)   陈碧, 刘文静, 张毛为,. 含糖皮质激素吸入制剂在支气管哮喘和慢性阻塞性肺疾病中的合理应用[J]. 中华结核和呼吸杂志, 2021, 44(8): 765-768.

(20)   Zhang Y#, Du H#, Li Y, Yuan Y, Chen B*, Sun S*. Elevated TRIM23 expression predicts cisplatin resistance in lung adenocarcinoma. Cancer Science. 2019 ,111 (2), 637-646.  

(21)   Guo M, Liu Y, Han X, Han F, Zhu J, Zhu S, Chen B*. Tobacco smoking aggravates airway inflammation by upregulating endothelin-2 and activating the c-Jun amino terminal kinase pathway in asthma. International Immunopharmacology, 2019 Oct 16;77:105916.   

(22)  Chen H, Zhang M, Zhang W, Li Y, Zhu J, Zhang X, Zhao L, Zhu S, Chen B*, Downregulation of BarH-like homeobox 2 promotes cell proliferation, migration and aerobic glycolysis through Wnt/β-catenin signaling, and predicts a poor prognosis in non-small cell lung carcinoma, Thorac Cancer, 2018, 9(3):390-399 

(23)   Xueqing Liu#, Bi Chen#, Wenjie You#, Shan Xue, Hui Qin, Handong Jiang*, The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2/STAT3 signaling pathway in non-small cell lung cancer, Cancer Lett, 2018, 412: 194-207.  

(24)   Bi Chen#, Wen-Jie You#, Xue-Qing Liu#, Shan Xue, Hui Qin, Han-Dong Jiang*, Chronic microaspiration of bile acids induces lung fibrosis through multiple mechanisms in rats. Clin Sci (Lond), 2017, 131(10): 951-963.

(25)   Bi Chen, Hou-rong Cai, Shan Xue, Wen-Jie You, Bin Liu, Han-dong Jiang*, Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways, Respirology, 2016, 21(6): 1075-1080  

(26)   Bi Chen#, Wen-Jie You#, Shan Xue#, Hui Qin, Xu-Ji Zhao, Miao Zhang, Xue-Qing Liu, Shu-Yang Zhu, Han-Dong Jiang*, Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease, J Thorac Dis, 2016,  8(11): 3063-3074 

(27)   孟晓, 奚斌, 张露, 刘文文, 张毛为,孙宜田, 张灿堂,刘平莉,陈碧*. 淋巴细胞计数对间质性肺疾病急性加重患者短期预后的预测价值. 国际呼吸杂志, 2024,44(05), 576-584.

(28)   张露,孟晓,奚斌, 刘文文,张毛为,孙宜田,张灿堂,刘文静,刘启明,陈碧*. SpO 2/FiO 2预测伴急性呼吸衰竭的间质性肺疾病患者预后的临床价值 [J]. 国际呼吸杂志,2024,44(10)1211-1219.


 

发表论文(近五年)
科研项目(近五年)
科研专利(近五年)
获奖成果
教材专著

研究方向

j间质性肺病的发病机制、诊断和治疗