张昕
专业型博导
职称:主任医师
13818832760
学院:麻醉学院
xinzhang3@njmu.edu.cn
个人简介

张昕,江苏无锡人,主任医师、医学博士、南京医科大学附属无锡市人民医院麻醉科科主任,美国杜克大学麻醉系Adjunct Assistant Professor。江苏卫生创新团领军人才、江苏特聘医学专家、江苏省“333高层次人才”培养对象。无锡市医学会麻醉学分会候任主任委员、无锡市医师协会麻醉科医师分会副会长、中华医学会麻醉学分会器官移植麻醉学组委员、中华医学会疼痛学分会头面痛学组委员、江苏省医学会疼痛学分会委员兼学术秘书。2016年以来主持及主要参与国家级课题5项。2017年以来发表SCI论文20+篇,被引用400+次。《Frontier in Pain Research》、《Frontier in Molecular Neuroscience》Associate Editor。


  • 临床工作

@ 南京医科大学附属无锡人民医院

  • 主任医师, 2021

@ 上海交通大学附属第六人民医院麻醉科

  • 副主任医师, 2015

  • 主治医师, 2009-2015

  • 住院医师,2002-2009

  • 研究工作

    Adjunct Assistant Professor,麻醉系,美国杜克大学 2021

    Assistant Professor,麻醉系,美国杜克大学 2020

    Research Scientist,  麻醉系,美国杜克大学 2019

    博士后,  麻醉系,美国杜克大学 2016

    博士,上海交交通大学医学院,2015

    硕士,上海交交通大学医学院,2011

    本科(临床医学),上海第二医科大学(现上海交通大学医学院),2002


 

论文情况(近五年)

·      Zhang L, Zhang X*, Wang Z, Li Y. Editorial: Molecular mechanism of neuroimmune modulation and synaptic plasticity in acute and chronic pain. Front Mol Neurosci. 2023 Jun 9;16:1224792. IF=6.261

·      Scarneo S, Zhang X*,, Wang Y, Camacho-Domenech J, Ricano J, Hughes P, Haystead T, Nackley AG. Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain. J Pain. 2023 Sep;24(9):1633-1644. IF= 7.926

·      Zhou Y, Qin Z, Wang G, Chen W, Zhang X#. Current status and training needs of trainee anesthesiologists in lung transplantation anesthesia in China: A single-center survey. Heliyon. 2022 Dec 19;8(12):e12428. IF= 3.776

·      Qian Y, Huang Z, Wang G, Han J, Zhou D, Ding H and Zhang X# (2022), Low-dose naloxone for prophylaxis of sufentanil-induced choking and postoperative nausea and vomiting. Front. Pharmacol. 13:1050847. IF= 5.998

·      Wang Y-W, Wang L, Yuan S-J, Zhang Y, Zhang X#  and Zhou L-T (2022) Postoperative Cognitive Dysfunction and Alzheimer’s Disease: A Transcriptome-Based Comparison of Animal Models. Front. Aging Neurosci. 14:900350. IF=4.504

·      Wang Y, Scarneo SA, Kim SH, Zhang X, Chen J, Yang KW, Hughes P, Haystead T, Nackley AG. Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. Pain. 2022 Jun 1;163(6):1091-1101. IF= 7.926

·      Chen Y, Wang ZL, Yeo M, Zhang QJ, López-Romero AE, Ding HP, Zhang X, Zeng Q, Morales-Lázaro SL, Moore C, Jin YA, Yang HH, Morstein J, Bortsov A, Krawczyk M, Lammert F, Abdelmalek M, Diehl AM, Milkiewicz P, Kremer AE, Zhang JY, Nackley A, Reeves TE, Ko MC, Ji RR, Rosenbaum T, Liedtke W. Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology. 2021 Jul;161(1):301-317.e16. IF= 29.4

·      Zhang X*,, Kanter, K., Chen, J., Kim, S., Wang, Y., Adeyemi, C., O'Buckley, S. C., and Nackley, A. G. (2020) Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice. Pain 161, 446-458IF= 7.926

·      Sun, L., Lv, Y., Tian, J., Yu, T., Niu, F., Zhang X#, and Du, D. (2019) Regular Swimming Exercise Attenuated Neuroma Pain in Rats: Involvement of Leptin and Adiponectin. The journal of pain : official journal of the American Pain Society 20, 1112-1124IF= 7.926

·      Yu T, Zhang X*, Shi H, Tian J, Sun L, Hu X, Cui W, Du D. P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents. Cell Death Dis. 2019 Feb 18;10(3):165. doi: 10.1038/s41419-019-1425-4. PMID: 30778044; PMCID: PMC6379416. IF= 9.0

·      Zhang X*,., Hartung, J. E., Bortsov, A. V., Kim, S., O'Buckley, S. C., Kozlowski, J., and Nackley, A. G. (2018) Sustained stimulation of beta2- and beta3-adrenergic receptors leads to persistent functional pain and neuroinflammation. Brain, behavior, and immunity 73, 520-532IF= 19.227

·      Zhang X*#,, Shi H, Zhou J, Xu Y, Pu S, Lv Y, Wu J, Cheng Y, Du D. The effectiveness of ultrasound-guided cervical transforaminal epidural steroid injections in cervical radiculopathy: a prospective pilot study. J Pain Res. 2018 Dec 31;12:171-177. IF= 2.581

·      Kim S, Zhang X*, O'Buckley SC, Cooter M, Park JJ, Nackley AG. Acupuncture Resolves Persistent Pain and Neuroinflammation in a Mouse Model of Chronic Overlapping Pain Conditions. J Pain. 2018 Dec;19(12):1384.e1-1384.e14. IF= 7.926

·      Han Q, Liu D, Convertino M, Wang Z, Jiang C, Kim YH, Luo X, Zhang X, Nackley A, Dokholyan NV, Ji RR. miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus. Neuron. 2018 Aug 8;99(3):449-463.e6. IF= 16.2

·      Tian J, Yu T, Xu Y, Pu S, Lv Y, Zhang X#  DU D. Swimming Training Reduces Neuroma Pain by Regulating Neurotrophins. Med Sci Sports Exerc. 2018 Jan;50(1):54-61. IF= 4.029


 

科研项目(近五年)

l  β2肾上腺素能受体调控皮肤角化细胞活化在慢性重叠型疼痛状态中的机制研究,2023.1-2026.12,国自然,52万,主持

l  A novel clinically- relevant mouse model of chronic overlapping pain conditions for screening analgesics,2022.4-2023.3,National Institutes of Health(美国国立卫生研究院),35万(美金),主持(PI)

l  皮肤角化细胞β肾上腺素能受体参与调控神经病理性疼痛的机制研究,2022/1-2023/12,无锡市卫生健康委科研重大项目,主持

糖尿病性神经痛中经BDNF/TrkB通路调控小胶质细胞极化平衡的机制研究,2015.1-2017.12,国自然,23万,主持


 

成果奖励(近五年)

l  2023年度  江苏卫生创新团队领军人才

l  2022年度  江苏特聘医学专家

l  2021年度 江苏省“333”人才第3层次培养对象

l  2018年 青年学者奖 美国疼痛医师协会

  l 2017年 青年学者奖 美国疼痛医师协会


 

发表论文(近五年)
科研项目(近五年)
科研专利(近五年)
获奖成果
教材专著

研究方向

危重症手术的麻醉管理