本科、硕士先后毕业于中国海洋大学生物工程和遗传学专业，2010年博士毕业于中国科学院动物研究所生物膜与膜生物工程国家重点实验室。2011年至2016年在美国University of North Carolina at Chapel Hill作为博士后研究p53的代谢调控功能。2016年全职加入徐州医科大学肿瘤生物治疗国家地方联合工程实验室，建立肿瘤代谢研究组，2017年入选江苏省特聘教授，2020年获徐州医科大学优秀研究人才计划支持，并于2020和2021年分别带队获得江苏省卫生创新团队（400万）和省“双创”团队（300万）支持。研究组从糖脂代谢角度出发，研究小分子代谢物对于肿瘤关键信号分子的修饰及功能影响，同时探索靶向肿瘤免疫微环境的新型代谢调控机制和肿瘤治疗策略。先后在包括PNAS、Cell Death & Differentiation、Trends in Cancer等刊物发表论文二十余篇，获得国家自然科学基金重大研究计划项目、面上项目、江苏省重点研发计划、江苏省高校重大研究项目资助。

 

1.      Yong Liu, Patrick L. Leslie, Yanping Zhang. Life-and-Death Decision-Making by p53 and Implications in Cancer Immunotherapy. Trends in Cancer. 7(3), P226-239, Mar 1, 2021 ( Co-corresponding author) (IF 11.09)

 

2.      Hao Cui, Hongjian Shan, Michael Zhe Miao, Zhiguo Jiang, Yuanyuan Meng, Ran Chen, Longzhen Zhang & Yong Liu. Identification of the key genes and pathways involved in the tumorigenesis and prognosis of kidney renal clear cell carcinoma. Scientific reports. 2020. Mar 6;10(1):4271. (Corresponding author) (IF 4.26)

 

3.       Nianli Liu,Zhiyuan Wu,Aoxing Chen,Yuqi Wang,Dafei Cai,Junian Zheng,Yong Liu & Longzhen Zhang. SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26. Cell Death & Disease. 2019. Sep; 10(9): 667 (Co-corresponding author)

 

4.      Liu, Yong, Leslie, Patrick, Jin, Aiwen, Itahana, Koji, Graves, Lee, and Zhang, Yanping. p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression. FASEB journal. 2018 Jul; 32(7): 3892–3902 (IF 5.49)

 

5.      Liu, Yong, Leslie, Patrick, Jin, Aiwen, Itahana, Koji, Graves, Lee, and Zhang, Yanping. p32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure. Scientific reports. 2017. 7(1), 5754. (IF 4.26)

 

6.      Liu, Yong, Chad Deisenroth, and Yanping Zhang. RP-MDM2-p53 pathway: linking ribosomal biogenesis and tumor surveillance. Trends in Cancer. April, 2016. 2(4), 191–204. (IF 11.09)

 

7.      Liu, Yong and Yanping Zhang. CHCHD2 connects mitochondrial metabolism to apoptosis. Molecular & Cellular Oncology. 2015 Oct-Dec ;2(4) (DOI: 10.1080/23723556.2015.1004964)

 

8.      Liu, Yong, Hilary V. Clegg, Jiehui Di, Laura A. Tollini, Yizhou He, Aiwen Jin, and Yanping Zhang. CHCHD2 inhibits apoptosis through interaction with Bcl-xL to regulate Bax activation. Cell Death and Differentiation. 2015 (22), 1035–1046 doi: 10.1038/ cdd.2014.194. (IF 10.07)

 

9.      Liu, Yong, Yizhou He, Aiwen Jin, Andrey P. Tikunov, Lishi Zhou, Laura A. Tollini, Patrick Leslie, Lei O. Li, Rosalind A. Coleman, Zhennan Gu, Yong Q. Chen, Jeffrey M. Macdonald, Lee M. Graves, and Yanping Zhang. The RP-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. 2014. PNAS USA. 2014 Jun 10;111(23): E2414-22. pii: 201315605. (IF 9.81)

 

10.    Liu Yong, Cheng He, Zhou Yuchang, Zhu Yushan, Bian Rui, Chen Yuewen, Li Changyin, Ma Qi, Zheng Qiaoxia, Zhang Yong, Jin Haijing, Wang Xiaohui, Chen Quan, Zhu Dahai. Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells. Cell Death & Disease. 2013. 4: e494; doi: 10.1038/ccdis.2013.31. (IF 5.99)

 

11.    Patrick L. Leslie, Derek A. Franklin, Yong Liu, Yanping Zhang. p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell Reports. 2018, 24, 1484–1495. (IF 8.28)

 

12.    Haitao Guo, Renate K?nig, Meng Deng, Maximilian Riess, Jinyao Mo, Lu, Zhang, Alex Petrucelli, Sunnie M. Yoh, Brice Barefoot, Melissa Ventevogel, Gregory D. Sempowski, Aiping Zhang, Anamaris M. Colberg-Poley, Hui Feng, Stanley M. Lemon, Yong Liu, Yanping Zhang, Haitao Wen, Zhigang Zhang, Blossom Damania, Li-Chung Tsao, Qi Wang, Lishan Su, Joseph A. Duncan, Sumit K. Chanda and Jenny P.-Y. Ting. NLRX1 antagonizes STING to attenuate innate immunity and promote replication of HIV-1 and DNA virus. Cell Host & Microbe. 19(4):515-28, 2016. (IF 14.95)

  

13.    Jing Zhang, Chengyang Wang, Xi Chen, Cheng Fan, Xingnan Zheng, Haitao Wen, Yong Liu, Chenguang Wang, Richard G. Pestell, William G. Kaelin Jr., X. Shirley Liu, and Qing Zhang. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO Journal. 2015 Dec 2;34(23):2953-70. (IF 9.64)

 

14.    Zhao xiangxuan, Yong Liu, Lei Du, Leya He, Biyun Ni, Junbo Hu, Dahai Zhu, Quan Chen. Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells. 2015. Protein & Cell. DOI 10.1007/s13238-014-0121-5. (IF 3.82)

 

15.    Bingzhang Jie, Xiaoxia Zhang, Xuesi Wu, Yi Xin, Yong Liu, Yongfang Guo. Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore. Molecular and Cellular Biochemistry. 2012 Nov, 370(1-2): 35-43. (IF 2.39)

 

16.    Ni Biyun, Ma Qi, Li Baowei, Zhao Lixia, Liu Yong, Zhu Yushan, Chen Quan. Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim. Clinical Cancer Research. 2012 Jan 1;18(1):140-51. (IF 8.19)

 

17.    Di Shao, Yang Liu, Xiaojun Liu, Liuluan Zhu, Ying Cui, Anfang Cui, Aijun Qiao, Xingxing Kong, Yong Liu, Quan Chen, Nishith Gupta, Fude Fang, Yongsheng Chang. PGC-1b-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRa. Mitochondrion. 10 (2010) 516–527. (IF 3.62)

 

18.    Yingli Shang, Yong Liu, Lei Du, Youliang Wang, Xuan Cheng, Weiming Xiao, Xiaohui Wang, Haijing Jin, Xiao Yang, Shusen Liu, and Quan Chen. Targeted Expression of Uncoupling Protein 2 to Mouse Liver Increases the Susceptibility to Lipopolysaccharide/ Galactosamine-Induced Acute Liver Injury. (2009) Hepatology, 50(4), 1204-1216. (IF 10.89)

 

序号	项目名称	起止时间	项目来源 与类别	获得资 助金额	本人 作用	项目进展与成果转化情况
１	基于p32-GCS1复合物的线粒体-内质网互作体系鉴定与功能研究	2021-2023	国家自然科学基金重大研究计划项目	83万元	负责	正在进行
２	MET-MCD负反馈调节环路在肾癌转移中的作用及分子机制研究	2020-2023	国家自然科学基金面上项目	55万元	负责	正在进行
３	CHCHD2及其介导的线粒体功能在乳腺癌转移中的作用机制研究	2017-2020	国家自然科学基金面上项目	57万元	负责	已完成
４	靶向HBV 治疗肝癌的CAR-T开发及临床前研究	2019-2022	江苏省重点研发计划项目	50万元	负责	正在进行