郭虹波,教授,博士生导师,一直致力于病毒与宿主相互作用的研究。博士毕业于荷兰乌得勒支大学,师从国际著名病毒学家Frank van Kuppeveld教授。荣获欧盟分子生物学会(EMBO)优秀青年科学家长期资助基金(Long-term Fellowship),以EMBO学者身份加盟德国海德堡大学Ralf Bartenschlager教授(拉斯克奖获得者)团队。
2021年全职加入徐州医科大学基础医学院、江苏省免疫与代谢重点实验室。主持国家自然基金青年项目、江苏省自然基金青年项目等基金项目,并荣获江苏省“双创博士”等人才称号。
在病毒学领域已发表SCI论文近30篇,其中以通讯(或第一)作者在PNAS、PLoS Pathogens、JHEP Reports、Emerging Infectious Diseases等领域内顶级期刊发表文章10篇。荣获荷兰皇家微生物学Kiem Awards(医学微生物领域),欧洲肝病学会Full Bursary Awards等学术奖励。
代表性论文(*通讯作者,#第一作者):
1. Guo H#*, Xu J#, Situ J#, Li C, Wang X, Hou Y, Yang G, Wang L, Ying D, Li Z, Wang Z, Su J, Ding Y, Zeng D, Zhang J, Ding X, Wu S, Miao W, Tang R, Lu Y, Kong H, Zhou P, Zheng Z, Zheng K*, Pan X*, Sridhar S*, Wang W*. Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humans. PNAS. 2024 Nov 5;121(45):e2416255121. (IF=9.4,中科院一区Top期刊)
2. Guo H#*, Li Q#, Li C, Hou Y, Ding Y, Liu D, Ni Y, Tang R, Zheng K, Urban S, Wang W*. Molecular determinants within the C-termini of L-HDAg that regulate hepatitis D virus replication and assembly. JHEP Reports. 2024;6(1):100961. (IF=9.5,中科院一区Top期刊)
3. Ding Y#, Guo H#*, Hong X#, Li Q, Miao Z, Pan Q*, Zheng K*, Wang W*. The distinct spatiotemporal evolutionary landscape of HBV and HDV largely determines the unique epidemic features of HDV globally. Mol Phylogenet Evol. 2024 Aug:197:108114. (中科院一区Top期刊)
4. Guo H#, Rabouw H, Slomp A, Dai M, van der Vegt F, van Lent JWM, McBride R, Paulson JC, de Groot RJ, van Kuppeveld FJM, de Vries E*, de Haan CAM*. Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces. PLoS Pathogens. 2018 Aug 13;14(8):e1007233. (中科院一区Top期刊)
5. Guo H#, de Vries E#, McBride R, Dekkers J, Peng W, Bouwman KM, Nycholat C, Verheije MH, Paulson JC, van Kuppeveld FJ, de Haan CA*. Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Emerging Infectious Diseases. 2017 Feb;23(2):220-231. (中科院Top期刊)
6. Guo H#*, Liu D#, Liu K, Hou Y, Li C, Li Q, Ding X, Verstegen MMA, Zhang J, Wang L, Ding Y, Tang R, Pan X, Zheng K, van der Laan LJW, Pan Q*, Wang W*. Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions. Virologica Sinica. 2024 02, 39(1): 123-133.
7. Zhang J, Li C, Hou Y, Liu D, Li Q, Wang Z, Tang R, Zheng K, Guo H*, Wang W*. miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15. Microbiology Spectrum. 2024;12(1):e0312423.
8. Guo H#, Urban S, Wang W*. In vitro cell culture models to study hepatitis B and D virus infection. Frontiers in Microbiology. 2023 Apr 5;14:1169770.