段新鹏，教授，硕士生导师，哈尔滨医科大学生理学博士（2018），美国纽约医学院药理学博士后（2019-2023），中国生理学会肾脏生理专业委员会青年委员（2025），江苏省生理科学学会青年委员（2024-2027）。现任职于徐州医科大学生理学教研室，生理学学科带头人（2025）。主要研究方向是肾脏离子通道与机体血压调节和钾平衡稳态的研究。基于多种基因敲除小鼠模型，利用电生理，肾脏清除率以及分子生物学技术探究肾脏Kir4.1, Kir5.1, ROMK等多种离子通道与相关转运蛋白之间的作用。目前发表本领域学术论文20余篇，包括JASN，Hypertension，JCI insight，Acta Physiol，AJP-renal physiology等本领域专业期刊。主持国家自然基金一项，江苏省高校课题面上基金一项。2024年入选江苏省科协青年科技人才托举工程。

 

1: Duan XP, Meng XX, Xiao Y, Zhang CB, Gu R, Lin DH, Wang WH. Kir4.1/Kir5.1 of

distal convoluted tubule is required for short-term angiotensin-II-induced

stimulation of Na-Cl cotransporter. Am J Physiol Renal Physiol. 2025 Jun

1;328(6):F775-F786. doi: 10.1152/ajprenal.00004.2025. Epub 2025 Apr 17. PMID:

40241495.

2: Duan XP, Zheng JY, Xiao Y, Zhang CB, Lin DH, Wang WH. Angiotensin II-Type-1a

Receptor and Renal K + Wasting during Overnight Low-Na + Intake. J Am Soc

Nephrol. 2024 Jun 24. doi: 10.1681/ASN.0000000000000429. Epub ahead of print.

PMID: 38913434.

3: Duan XP, Zhang CB, Wang WH, Lin DH. Role of calcineurin in regulating renal

potassium (K⁺) excretion: Mechanisms of calcineurin inhibitor-induced

hyperkalemia. Acta Physiol (Oxf). 2024 Aug;240(8):e14189. doi:

10.1111/apha.14189. Epub 2024 Jun 11. PMID: 38860527; PMCID: PMC11250626.

4: Duan XP, Zheng JY, Jiang SP, Wang MX, Zhang C, Chowdhury T, Wang WH, Lin DH.

mTORc2 in Distal Convoluted Tubule and Renal K + Excretion during High Dietary K

+ Intake. J Am Soc Nephrol. 2024 May 24. doi: 10.1681/ASN.0000000000000406. Epub

ahead of print. PMID: 38788191.

5: Duan XP, Xiao Y, Su XT, Zheng JY, Gurley S, Emathinger J, Yang CL, McCormick

J, Ellison DH, Lin DH, Wang WH. Role of Angiotensin II Type 1a Receptor (AT1aR)

of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2

(Kir4.2), Kir4.1, and Epithelial Na⁺ Channel (ENaC). Hypertension.

2024 Jan;81(1):126-137. doi: 10.1161/HYPERTENSIONAHA.123.21389. Epub 2023 Nov 1.

PMID: 37909221; PMCID: PMC10842168.

6: Zhang DD, Duan XP, Mutig K, Rausch F, Xiao Y, Zheng JY, Lin DH, Wang WH.

Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule

to increase NaCl cotransporter. JCI Insight. 2023 Apr 10;8(7):e165987. doi:

10.1172/jci.insight.165987. PMID: 36821372; PMCID: PMC10132170.

7: Duan XP, Wu P, Zhang DD, Gao ZX, Xiao Y, Ray EC, Wang WH, Lin DH. Deletion

of Kir5.1 abolishes the effect of high Na⁺ intake on Kir4.1 and

Na⁺-Cl^- cotransporter. Am J Physiol Renal Physiol. 2021

Jun 1;320(6):F1045-F1058. doi: 10.1152/ajprenal.00004.2021. Epub 2021 Apr 26.

PMID: 33900854; PMCID: PMC8285650.

8: Zhang DD, Duan XP, Xiao Y, Wu P, Gao ZX, Wang WH, Lin DH. Deletion of renal

Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC

and causes hypokalemia during high HS. Am J Physiol Renal Physiol. 2021 May

1;320(5):F883-F896. doi: 10.1152/ajprenal.00555.2020. Epub 2021 Apr 5. PMID:

33818128; PMCID: PMC8174810.

9: Duan XP, Gu L, Xiao Y, Gao ZX, Wu P, Zhang YH, Meng XX, Wang JL, Zhang DD,

Lin DH, Wang WH, Gu R. Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is

Required for the Activation of NaCl Transporter in Distal Convoluted Tubule.

Hypertension. 2019 Jan;73(1):112-120. doi: 10.1161/HYPERTENSIONAHA.118.11621.

PMID: 30571558; PMCID: PMC6319266.

 

1. 国家自然科学基金青年科学基金项目, 81900648，主持 

2. 江苏省高等学校自然科学研究面上项目, 19KJB31001, 主持