姚瑶，博士、副教授、硕士生导师，江苏省“六大人才高峰”高层次人才，江苏省高校“青蓝工程”中青年学术带头人。主要从事多发性骨髓瘤的发病机制与靶向治疗研究。2016年在徐州医科大学附属医院完成博后工作，2019-2022年在哈佛医学院附属Dana Farber肿瘤研究所完成博后工作。近年，主持国家自然科学基金面上项目1项、国家自然科学基金青年基金1项、江苏省教育厅重大项目等省部级项目6项。获得江苏省医学新技术引进奖一等奖1项。发表SCI收录论文数篇。

我们以徐州医科大学附属医院血液科和江苏省骨髓干细胞重点实验室为依托，为研究生提供优越的科研平台，且实验室具有良好的科研氛围。欢迎有志于从事多发性骨髓瘤等血液肿瘤研究的同学们报考研究生（学术型），为癌症研究贡献一份力量。

 

1. Yao Yao, Jessica Fong Ng, Woojun Daniel Park, Mehmet K. Samur, Eugenio  Morelli, Jessica Encinas, Zuzana Chyra, Yan Xu, Sanika Derebail, Charles B. Epstein, Behnam Nabet, Marta Chesi, Nathanael S Gray, Richard Young, Nicholas Kwiatkowski, Constantine S. Mitsiades, Kenneth C. Anderson,  Charles Y. Lin, Nikhil C. Munshi*, Mariateresa Fulciniti*.  CDK7 controls E2F- and MYC driven proliferative and metabolic vulnerabilities in multiple myeloma, Blood, 2023, 141(23): 2841-2853. (IF:21，一区).

2. Sha Ma^#, Jieyun Xia^#, Miao Zhang^#, Wenyu Li^#,  Meng Xiao, Yuqian Sha, Wenya Wang, Jianteng Zhou, Ying Wang, Kunming Qi, Chunling Fu, Zengtian Sun, Dian Zhou, Qian Sun, Tingting Qiu, Zhiling Yan, Feng Zhu, Wei Chen, Hai Cheng, Wei Sang, Jiang Cao, Depeng Li, Zhenyu Li, Mariateresa Fulciniti, Yao Yao （通讯作者）* , Kailin Xu*, Mingshan Niu*, Genetic and epigenetic mechanisms of GPRC5D loss after anti-GPRC5D CAR T-cell therapy in multiple myeloma.  Blood,2025 Mar 16:blood.2024026622. (IF:21，一区).

3. Yao Yao, Shuhui Deng, Jessica Fong Ng, Mei Yuan, Chandraditya Chakraborty, Vera Joy Weiler, Nikhil Munshi, Mariateresa Fulciniti?. Unlocking the therapeutic potential of selective CDK7 and BRD4 Inhibition against multiple myeloma cells. Haematologica.  2025 Jan 1;110(1):153-162. (IF:8.2，一区）.

4.Yao Yao^#*,  Mei Yuan^#, Min Shi, Wenyu Li, Yan Zhang, Canli Yuan, Jianping Luo, Yuqian Sha, Zhenyu Li, Chengcheng Liao, Kailin Xu*, Mingshan Niu*. Halting Multiple Myeloma with MALT1 Inhibition: Suppressing BCMA-Induced NF-κB and Inducing Immunogenic Cell Death. Blood Advances. 2024 Aug, 13;8(15):4003-4016. (IF:7.4，一区）.

5.Ting Du, Yan Song, Arghya Ray, Xueping Wan, Yao Yao,  Mehmet K. Samur, Chen Shen, Johany Penailillo, Tomasz Sewastianik, Yu-Tzu    Tai, Mariateresa Fulciniti, Nikhil C. Munshi, Hao Wu, Ruben D. Carrasco, Dharminder Chauhan, Kenneth C. Anderson. Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma. Blood. 2023May25,141(21): 2599-2614.（IF:21，一区).

6. Yan Xu, Mariateresa Fulciniti, Mehmet K. Samur, Matthew Ho, Shuhui Deng, Lanting Liu, Kenneth Wen, Tengteng Yu, Zuzana Chyra, Sanika Dereibal, Li Zhang, Yao Yao, Chandraditya Chakraborty,      Eugenio Morelli, Na Li, Michael A. Lopez, Tommaso Perini, Shidai Mu, Gang  An, Rafael Alonso, Giada Bianchi, Yu-Tzu Tai, Kenneth C. Anderson, Lugui Qiu, and Nikhil C. Munshi. YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood. 2020 Jul 23, 136(4): 468–479. （IF:21，一区).

7. Zhiling Yan, Jiang Cao, Hai Cheng, Jianlin Qiao, Huanxin Zhang, Ying Wang, Ming Shi, Jianping Lan, Xiaoming Fei, Lai Jin, Guangjun Jing, Wei Sang, Feng Zhu, Wei Chen, Qingyun Wu, Yao Yao, Gang Wang, Jing Zhao, Junnian Zheng, Zhenyu Li, Kailin Xu. A combination of humanised anti-CD19 and anti-BCMA CAR T cells in patients with relapsed or refractory multiple myeloma: a single-arm, phase 2 trial. Lancet Haematol. 2019 Oct,6(10):e521-e529. （IF:24.7,一区）.

8. Rafael Alonso Fernandez, Jessica Encinas Mayoral, Laetitia Pierre-Louis, Yao Yao, Yan Xu, Shidai Mu, Joaquin Martinez-Lopez, Daniel Primo, Takahiro Miyazaki, Rao Prabhala, Kenneth C. Anderson, Willem W. Overwijk, Nikhil C. Munshi, and Mariateresa Fulciniti. Improving NK cell function in multiple myeloma with NKTR-255, a novel  polymer-conjugated human IL-15. Blood Advances. 2023 Jan      10,7(1):9-19. (IF:7.5,一区）.

9. Yao Yao, Yan Zhang, Min Shi, Yueyue Sun, Chong Chen, Mingshan Niu, Qi Zhang, Lingyu Zeng, Ruosi Yao, Hujun Li, Jiajia Yang, Zhenyu Li, Kailin Xu , Blockade of deubiquitinase USP7 overcomes bortezomib resistance by suppressing NF-κB signaling pathway in multiple myeloma, Journal of Leukocyte Biology, 2018, 1104(6): 1105-1115. （IF:5.5）.

10. Canli Yuan, Mei Yuan, Wenyu Li, Hai Cheng,  Jianping Luo, Qi Zhang, Mengya Shi, Mingshan Niu, Jiajia Yang, Zengtian Sun, Zhiling Yan, Kailin Xu, Zhenyu Li, Yao Yao （通讯作者）* . The STAT3 inhibitor stattic overcome  bortezomib-resistance in multiple myeloma via decreasing PSMB6, Experimental  Cell Research, 2023, 429(1): 113634. （IF:3.7）.

11. Mingshan Niu, Ninghan Zhang, Rong Wang, Tingting Shao, Yuan Feng, Yangling Shen, Xuejiao Liu, Kai Zhao, Shengyun Zhu, Linyan Xu, Yao Yao （通讯作者）* , Kailin Xu?, MiR-340 Is a Biomarker for Selecting Treatment Between Chemotherapy and Allogeneic  Transplantation in Acute Myeloid Leukemia, Frontiers in Oncology,  2019, 9: 1058. （IF:4.7）.