1992年北京大学医学部（原北京医科大学）基础医学系获医学学士学位，1998年北京大学医学部免疫学系获免疫学博士学位。先后分别在美国耶鲁大学、芝加哥大学以及加州Genentech公司做博士后、研究助理教授及资深研究助理工作。2016年加入徐州医科大学，被聘为徐州医科大学基础医学院教授，江苏省特聘教授。研究方向是慢性代谢性炎性疾病的免疫与代谢调控研究。关注的重点有：1）肠道微生态与机体的免疫与代谢调控；2）脂肪组织的免疫与代谢调控；3）组织损伤修复的免疫代谢调控。以通讯作者或第一作者在 “Science”、“Immunity”、”Nature communications”、“JCI Insight” 等发表多篇科研论文。课题获得国家自然科学基金面上项目资助。

近5年内发表的论著

1.       4-Hydroxybenzoic acid restrains Nlrp3 inflammasome priming and activation via disrupting PU.1 DNA binding activity and direct antioxidation. Kou Y, Jing Q, Yan X, Chen J, Shen Y, Ma Y, Xiang Y, Li X, Liu X, Liu Z, Wei Y, Wang Y. Chem Biol Interact. 2024 Oct 8:111262. doi:10.1016/j.cbi.2024.111262. Online ahead of print. PMID: 39389441

2.       A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner. Kou Y, Zhang S, Chen J, Shen Y, Zhang Z, Huang H, Ma Y, Xiang Y, Liao L, Zhou J, Cheng W, Zhou Y, Yang H, Liu Z, Wei Y, Wang H, Wang Y. Nat Commun. 2024 Sep 10;15(1):7914. doi: 10.1038/s41467-024-52336-z. PMID: 39256385 Free PMC article.

3.       Desaminotyrosine is a redox-active microbial metabolite that bolsters macrophage antimicrobial functions while attenuating IL-6 production. Zhou J, Han J, Wei Y, Wang Y. FASEB J. 2024 Jul 31;38(14):e23844. doi: 10.1096/fj.202400638R. PMID: 39046365

4.       Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism. Liu Z, Wang H, Zhang Z, Ma Y, Jing Q, Zhang S, Han J, Chen J, Xiang Y, Kou Y, Wei Y, Wang L, Wang Y. PLoS Negl Trop Dis. 2024 May 7;18(5):e0012163. doi: 10.1371/journal.pntd.0012163. eCollection 2024 May. PMID: 38713713 Free PMC article.

5.       A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response. Yang H, Wu X, Li X, Zang W, Zhou Z, Zhou Y, Cui W, Kou Y, Wang L, Hu A, Wu L, Yin Z, Chen Q, Chen Y, Huang Z, Wang Y, Gu B. Nat Commun.2024 Apr 2;15(1):2842. doi: 10.1038/s41467-024-47075-0. PMID: 38565558 Free PMC article.

6.       Dietary ingredient change induces a transient MyD88-dependent mucosal enteric glial cell response and promotes obesity. Liu Z, Sun H, Xu S, Wang H, Zhang Z, Wei Y, Kou Y, Wang Y. Nutr Neurosci.2023 Dec;26(12):1183-1193. doi: 10.1080/1028415X.2022.2142129. Epub 2022 Nov 7. PMID: 36342063

7.       FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice. Liu Z, Xu S, Zhang Z, Wang H, Jing Q, Zhang S, Liu M, Han J, Kou Y, Wei Y, Wang L, Wang Y. Free Radic Biol Med. 2022 Nov 1;192:115-129. doi: 10.1016/j.freeradbiomed.2022.09.011. Epub 2022 Sep 20. PMID: 36150559