颜超，副教授，微生物学博士，先后入选江苏省“333高层次人才培养工程”项目（2022）、江苏省“青蓝工程”（2018年）等人才项目；获得江苏省教育教学与研究成果奖（高校自然科学类）一等奖（2/5，2018年）、第六届淮海科学技术科技创新奖一等奖（3/10，2018年）、江苏省政府留学奖学金（2016年）等荣誉或奖励；先后主持国家自然项目（青年项目）1项，江苏省自然基金面上项目2项，作为骨干参与国家自然基金面上项目3项；以第一作者或通讯作者在Proc Natl Acad Sci U S A（第一作兼并列通讯作者，2021）、Hepatology（第一作者，2020）、Frontiers in Immunology（通讯作者，2021）、PLoS Negl Trop Dis（第一作者，2022，2020）等国际权威期刊发表 SCI 论文25篇，单篇最高影响因子17.425；申报国家发明专利3件，其中授权2件。

 

[1]    颜超，江苏省“333高层次人才培养工程”（第三层次）项目入选者，2022年

[2]    颜超，江苏省“青蓝工程”人才项目（优秀骨干教师）培养对象，2018年

[3]    郑葵阳，颜超，汤仁仙，李向阳，于倩，固有免疫在华支睾吸虫致胆管周纤维化中的调控作用，江苏省教育厅，江苏省教育科学研究成果奖（高校自然科学类），一等奖，2018

[4]    郑葵阳、汤仁仙、颜超、于倩、华慧、李向阳、刘转转、张波、李妍、刘宜升，华支睾吸虫感染源性肝胆管周纤维化致病新机制，淮海科学技术奖委员会，第六届淮海科学技术奖科技创新奖，一等奖，2018年

 

[1]      Yan C^#,*, Zhou QY^#, Wu J^#, Xu N, Du Y, Li J, Liu JX, Koda S, Zhang BB, Yu Q, Yang HM, Li XY, Zhang B, Xu YH, Chen JX, Wu Z, Zhu XQ, Tang RX*, Zheng KY*. Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries. Proc Natl Acad Sci U S A. 2021, 16;118(46): e2102206118.  IF:11.205

[2]      Yan C^#, Koda S^#, Wu J, Zhang BB, Yu Q, Netea MG, Tang RX*, Zheng KY*. Roles of trained immunity in the pathogenesis of cholangiopathies: a therapeutic target. Hepatology. 2020, 72(5):1838-1850.  IF:17.425

[3]      Koda S^#, Zhang B^#, Zhou QY, Xu N, Li J, Liu JX, Liu M, Lv ZY, Wang JL, Shi Y, Gao S, Yu Q, Li XY, Xu YH, Chen JX, Tekengne BOT, Adzika GK, Tang RX, Sun H, Zheng KY*, Yan C*. β2-Adrenergic receptor enhances the alternatively activated macrophages and promotes biliary injuries caused by helminth infection. Front Immunol. 2021;12:754208. IF:7.561

[4]      Yan C^#, Fang F^#, Zhang YZ, Dong X, Wu J, Liu HL, Fan CY, Koda S, Zhang BB, Yu Q, Wang L, Wang YG, Chen JX, Zheng KY*. Recombinant CsHscB of carcinogenic liver fluke Clonorchis sinensis induces IL-10 production by binding with TLR2. PLoS Negl Trop Dis. 2020;14(10):e0008643. IF:4.411

[5]      Yan C^#,*, Wu J^#, Xu N, Li J, Zhou QY, Yang HM, Cheng XD, Liu JX, Dong X, Koda S, Zhang BB, Yu Q, Chen JX, Tang RX, Zheng KY*. TLR4 deficiency exacerbates biliary injuries and peribiliary fibrosis caused by Clonorchis sinensis in a resistant mouse strain. Front Cell Infect Microbiol. 2021;10:526997. IF:5.293

[6]    Zhou QY, Yang HM, Liu JX, Xu N, Li J, Shen LP, Zhang YZ, Koda S, Zhang BB, Yu Q, Chen JX, Zheng KY*, Yan C*. MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7. Parasit Vectors. 2021;14(1):472. IF:3.876

[7]    Koda S, Zhu XQ, Zheng KY*, Yan C*. Molecular mechanisms of Clonorchis sinensis-host interactions and implications for vaccine development. Front Cell Dev Biol, 2022;9:781768.  IF:6.684

[8]      Li B^#, Yan C^#,*, Wu J, Stephane K, Dong X, Zhang YZ, Zhang Y, Yu Q, Zheng KY*. Clonorchis sinensis ESPs enhance the activation of hepatic stellate cells by a cross-talk of TLR4 and TGF-β/Smads signaling pathway. Acta Trop. 2020;205:105307. IF:3.112

[9]      Hua H^#, Du Y^#, Ma R, Zhang BB, Yu Q, Li B, Xu JT, Li XY, Tang RX, Yan C*, Zheng KY*. The regulatory roles of toll-like receptor 4 in secretions of type 1/type 2 relative cytokines by splenocytes and dendritic cells exposed to Clonorchis sinensis excretory/secretory products. Inflammation. 2018;41(1):213-220.  IF:4.092

[10]   Yan C^#, Li B^#, Fan F, Du Y, Ma R, Cheng XD, Li XY, Zhang B, Yu Q, Wang YG, Tang RX*, Zheng KY*. The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis. Sci Rep. 2017;7(1):3909.  IF:4.379

[11]   Zhang BB^#, Yan C^#, Fang F, Du Y, Ma R, Li XY, Yu Q, Meng D, Tang RX*, Zheng KY*. Increased hepatic Th2 and Treg subsets are associated with biliary fibrosis in different strains of mice caused by Clonorchis sinensis. PLoS One. 2017;12(2):e0171005. IF:3.24

[12]   Yan C^#, Shen LP^#, Ma R, Li B, Li XY, Hua H, Zhang B, Yu Q, Wang YG, Tang RX*, Zheng KY*. Characterization and identification of differentially expressed microRNAs during the process of the peribiliary fibrosis induced by Clonorchis sinensis. Infect Genet Evol. 2016;43:321-328. IF:3.342

[13] Yan C, Liang LJ, Zheng KY*, Zhu XQ*. Impact of environmental factors on the emergence, transmission and distribution of Toxoplasma gondii. Parasit Vectors. 2016;9:137. IF: 3.876

[14]   Yan C^#, Wang YH^#, Yu Q, Cheng XD, Zhang BB, Li B, Zhang B, Tang RX*, Zheng KY*. Clonorchis sinensis excretory/secretory products promote the secretion of TNF-alpha in the mouse intrahepatic biliary epithelial cells via Toll-like receptor 4. Parasit Vectors. 2015;8:559. IF:3.876

[15]   Yan C^#, Wang L^#, Li B, Zhang BB, Zhang B, Wang YH, Li XY, Chen JX, Tang RX*, Zheng KY*. The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis. Parasit Vectors. 2015;8:70. IF:3.876

 

[1]    颜超; 郑葵阳; 汤仁仙; 张雨钊; 范春阳; 李向阳; 华慧; 董昕; 于倩; 张波;华支睾吸虫重组蛋白CsHscB及其在肠炎治疗药物中的应用, 2019-6-4, 中国, ZL201910479535.4. 2021-4-13（已授权）

[2]    郑葵阳; 颜超; 汤仁仙; 沈莉萍; 于倩; 李向阳; 华慧; 张波; 一种miR-497-5p的抑制剂及其在制备肝纤维化药物中的应用, 2018-8-16, 中国, ZL201810934325.5. (专利)，2021-4-06（已授权）

[3]    颜超; 郑葵阳; 汤仁仙; 张钰; 于倩; 张雨钊; 武婧; 华慧; 李向阳; 范春阳;张波; 华支睾吸虫重组蛋白CsHscB在胆汁淤积性肝纤维化治疗药物中的应用, 2019-6-4，中国, CN201910479451.0.

 

（1）人体寄生虫学（理论+实验） 临床定向以及急救专业；

（2）病原生物学（理论+实验）  药物、临床药学专业

（3）医学免疫学（实验）全校硕士研究生