汤道权
硕士生导师
职称：教授
学院：药学院
tangdq@xzhmu.edu.cn
个人简介

 中共党员，教授，药学博士。江苏高校青蓝工程优秀青年骨干教师，徐州医学院中青年学术带头人、优秀青年骨干教师。全国高等教育医学会药学分会委员，江苏省药理学会理事，江苏省高等学校医药教育研究会理事，徐州药学会理事，淮海科技奖专家库成员，徐州市应急管理专家组成员。

 

成果奖励（近五年）

 

  1. 江苏省高校科学技术研究类自然科学奖三等奖：体内外复杂体系中几类成分分析方法的建立及应用. 无证书编号。授予单位：江苏省教育厅。获奖时间：2018.7。本人排名：第一。

  2. 淮海科学技术奖一等奖：中药色谱指纹图谱结合多组分定量质量控制模式的建立及其应用. 证书编号：2016-HJC-1-8-1。授予单位：淮海科学技术奖委员会。获奖时间：2016.9。本人排名：第一。

  3. 江苏省高校科学技术研究类自然科学奖三等奖：8种中药质控模式的建立及其在银杏叶提取物活性成分发现中应用. 无证书编号。授予单位：江苏省教育厅。获奖时间：2016.7。本人排名：第一。

 

科研项目（近五年）

 

  1. 江苏省中医药管理局专题研究项目：基于“宿主-肠道微生物”共代谢的六味地黄丸对DN的改善作用及分子机制研究。项目编号：ZT202212。项目起止时间：2023.1~2025.12。项目经费：24万元。本人角色：项目主持人。

  2. 徐州市科技计划项目：基于代谢组学和微生物组学的二甲双胍联合桑叶对T2D的治疗作用及潜在机制研究。项目编号：KC21204。项目起止时间：2021.7~2023.6。项目经费：5万元。本人角色：项目主持人。

  3. 江苏省自然科学基金社会发展项目：癫痫类药物治疗药物监测技术的构建及其在个体化治疗中的应用。项目编号：BE2019640。项目起止时间：2019.7~2022.6。项目经费：50万元。本人角色：项目主持人。

  4. 江苏省自然科学基金面上项目：抗癫痫药物HS-SPE/GC-MS分析方法的构建及其在临床血药浓度监测中的应用。项目编号：BK20181147。项目起止时间：2018.7~2021.6。项目经费：10万元。本人角色：项目主持人。

  5. 徐州市自然科学基金：石墨烯量子点/分子印迹聚合物复合膜的构建及其在卡马西平/奥卡西平精准药物治疗中的应用。项目编号：KC17187。项目起止时间：2017.9~2020.8。项目经费：5万元。本人角色：项目主持人。

  6. 江苏省高校自然科学基金重大项目：细胞动态代谢组学探寻糖尿病肾病形成过程的生物标志物。项目编号：16KJA350001。项目起止时间：2016.9~2019.8。项目经费：30万元。本人角色：项目主持人。


 

论文情况（近五年）

 

  1. Jin P#, You YX#, Zhao LL, Zhao YL, Zheng XX, Du Y, Tang DQ*. A simple and easy non-derivatization GC-MS method for simultaneous quantification of valproic acid, gabapentin, pregabalin and vigabatrin in human plasma. J Sep Sci. 2023; 46(2):e2200622.

  2. Shao X#, Chen X#, Wang Z, Zhu C, Du Y, Tang D*, Ji S**. Diprenylated flavonoids from licorice induce death of SW480 colorectal cancer cells by promoting autophagy: Activities of lupalbigenin and 6,8-diprenylgenistein. J Ethnopharmacol. 2022 Oct 5; 296:115488.

  3. Zhao YL#, Zhao LL#, You YX, Zheng XX, Du Y, Tang DQ*. Development and evaluation of a simple and easy HPLC-UV system simultaneously suitable for determination of 24 anti-epileptic drugs in plasma. J Sep Sci. 2022 Jul; 45(13):2161-2176. 

  4. Wei YQ#, Zhao LL#, You YX#, Zhao YL, Zheng XX, Du Y, Tang DQ*. Development of magnetic molecularly imprinted polymers with double templates for the rapid and selective determination of carbamazepine and lamotrigine in serum. RSC Advances. 2022; 12(16):10051-10061. 

  5. Du Y#, Li DX#, Lu DY#, Zhang R, Zhao YL, Zhong QQ, Ji S, Wang L, Tang DQ*. Lipid metabolism disorder and lipid mediator changes of mice in response to long-term exposure to high-fat and high sucrose diet and ameliorative effects of mulberry leaf. Food Funct. 2022, 13(8):4576-4591. 

  6. Zhang F#, Li DX#, Lu DY#, Lu YF, Zhang R, Zhao LL, Ji S, Guo MZ, Du Y, Tang DQ*. Analysis of plasma free amino acids in diabetic rat and the intervention of Ginkgo biloba leaves extract using hydrophilic interaction liquid chromatography coupled with tandem mass-spectrometry. Journal of Chromatography B. 2022; 1196:123230.

  7. Lu YF, Li DX, Zhang R, Zhao LL, Qiu Z, Du Y, Ji S, Tang DQ*. Chemical Antioxidant Quality Markers of Chrysanthemum morifolium Using a Spectrum-Effect Approach. Front Pharmacol. 2022 Feb 7; 13:809482.

  8. Du Y#, Li DX#, Lu DY#, Zhang R, Zhong QQ, Zhao YL, Zheng XX, Ji S, Wang L, Tang DQ*. Amelioration of lipid accumulations and metabolism disorders in differentiation and development of 3T3-L1 adipocytes through mulberry leaf water extract. Phytomedicine. 2022 Jan 29; 98:153959.

  9. Du Y#, Li DX#, Lu DY#, Zhang R, Zheng XX, Xu BJ, Zhao YL, Ji S, Guo MZ, Wang L, Tang DQ*. Morus alba L. water extract changes gut microbiota and fecal metabolome in mice induced by high-fat and high-sucrose diet plus low-dose streptozotocin. Phytother Res. 2022 Mar; 36(3):1241-1257.

  10. Zhao L#, Chen X#, Shao X, Wang Z, Du Y, Zhu C, Du W, Tang D*, Ji S*. Prenylated phenolic compounds from licorice (Glycyrrhiza uralensis) and their anti-inflammatory activity against osteoarthritis. Food Funct. 2022 Jan 24; 13(2):795-805.

  11. Ji S*, Zhu C, Gao S, Shao X, Chen X, Zhang H, Tang D*. Morus alba leaves ethanol extract protects pancreatic islet cells against dysfunction and death by inducing autophagy in type 2 diabetes. Phytomedicine. 2021; 83:153478.

  12. Wu J#, Zhong QQ#, Wang TY#, Wang CX, Du Y, Ji S, Wang L, Guo MZ, Tang DQ*. MS-based metabolite analysis of two licorice chalcones in mice plasma, bile, feces, and urine after oral administration. Biomed Chromatogr. 2021; 35(3):e4998. 

  13. Wang M#, Liu Q#, Kang X, Zhu Z, Yang H, Xi X, Zhang X, Du Y, Guo M, Tang D*, Wang L*. Glycogen Metabolism Impairment via Single Gene Mutation in the glgBXCAP Operon Alters the Survival Rate of Escherichia coli Under Various Environmental Stresses. Front Microbiol. 2020; 11:588099.

  14. Ji S*, Wang YJ, Shao X, Zhu CC, Lin Y, Gao SK, Tang DQ*. Extraction and purification of triterpenoid saponins from licorice by ionic liquid based extraction combined with in situ alkaline aqueous biphasic systems. Sep Purif Technol. 2020; 247:116953.

  15. Zhang L, Wang CX, Wu J, Wang TY, Zhong QQ, Du Y, Ji S, Wang L, Guo MZ, Xu SQ, Tang DQ*. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones. J Ethnopharmacol. 2020; 257:112892.

  16. Guo M, Du W, Lyu N, Chen X, Du Y, Wang H, Yang D, Wu S, Liang J, Pan Y, Tang D*. Ultra-Early Diagnosis of Acute Myocardial Infarction in Rats Using Ultrasound Imaging of Hollow Double-Layer Silica Nanospheres. Adv Healthc Mater. 2020; 9(3):e1901155.

  17. Ji S#, Wang YJ#, Gao SK, Shao X, Cui W, Du Y, Guo MZ, Tang DQ*. Highly efficient and selective extraction of minor bioactive natural products using pure ionic liquids: Application to prenylated flavonoids in licorice. J Ind Eng Chem. 2019; 80:352-360.

  18. Wang L#, Du Y#, Xu BJ#, Deng X, Liu QH, Zhong QQ, Wang CX, Ji S, Guo MZ, Tang DQ*. Metabolomics study of metabolic changes in renal cells in response to high-glucose exposure based on liquid or gas chromatography coupled with mass spectrometry. Front Pharmacol. 2019; 10:928.

  19. Wang L#, Liu Q#, Tan X, Wang Z, Wang M, Wise MJ, Li C, Ma C, Li E, Deng B, Du Y, Tang D*, Gilbert RG*. Molecular Structure of Glycogen in Escherichia coli. Biomacromolecules. 2019; 20(7):2821-2829.

  20. Ji S#, Shao X#, Su ZY, Ji L, Wang YJ, Ma YS, Zhao L, Du Y, Guo MZ, Tang DQ*. Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet. J Pharm Biomed Anal. 2019; 174:367-375.

  21. Guo MZ, Shao L, Chen X, Li HJ, Wang L, Pan YJ, Tang DQ*. Assay of dried blood spot from finger prick for sodium valproate via ink auxiliary headspace gas chromatography mass spectrometry. J Chromatogr A. 2019; 1601:335-339.

  22. Yao Y, Zhao D, Li N, Shen F, Machuki JO, Yang D, Li J, Tang D*, Yu Y, Tian J, Dong H, Gao F*. Multifunctional Fe3O4@Polydopamine@DNA-Fueled Molecular Machine for Magnetically Targeted Intracellular Zn2+ Imaging and Fluorescence/MRI Guided Photodynamic-Photothermal Therapy. Anal Chem. 2019; 91(12):7850-7857.

  23. Qiu J#, Chen W#, Zhang Y, Zhou Q, Chen J, Yang L, Gao J*, Gu X*, Tang D*. Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors. Eur J Med Chem. 2019; 176:41-49.

  24. Guo M, Shao L, Du Y, Qian Z, Huang T, Tang D*. Microporous polymer based on the new compound "bi-(4-vinyl phenylquinoline) amide" for enrichment and quantitative determination of lamotrigine in rat and human serum. Anal Bioanal Chem. 2019; 411(15):3353-3360.

  25. Yao Y, Li N, Zhang X, Ong'achwa Machuki J, Yang D, Yu Y, Li J, Tang D*, Tian J, Gao F*. DNA-Templated Silver Nanocluster/Porphyrin/MnO2 Platform for Label-Free Intracellular Zn2+ Imaging and Fluorescence-/Magnetic Resonance Imaging-Guided Photodynamic Therapy. ACS Appl Mater Interfaces. 2019; 11(15):13991-14003.

  26. Yu Y#, Yin T#, Peng Q, Kong L, Li C, Tang D*, Yin X*. Simultaneous Monitoring of Amyloid-β (Aβ) Oligomers and Fibrils for Effectively Evaluating the Dynamic Process of Aβ Aggregation. ACS Sens. 2019; 4(2):471-478.

  27. Ji S #, He DD #, Su ZY, Du Y, Wang YJ, Gao SK, Guo MZ, Tang DQ*. P450 enzymes-based metabolic interactions between monarch drugs and the other constituent herbs: A strategy to explore compatibility mechanism of Sangju-Yin. Phytomedicine. 2019; 58:152866.

  28. Guo MZ, Wang TY, Yang J, Chang H, Ji S, Tang DQ*. Interaction of clopidogrel and fufang danshen dripping pills assay in coronary heart disease based on non-target metabolomics. J Ethnopharmacol. 2019; 234:189-196.

  29. Zheng XX #, Du Y #, Xu BJ #, Wang TY, Zhong QQ, Li Z, Ji S, Guo MZ, Yang DZ, Tang DQ*. Off-line two-dimensional liquid chromatography coupled with diode array detection and quadrupole-time of flight mass spectrometry for the biotransformation kinetics of Ginkgo biloba leaves extract by diabetic rat liver microsomes. J Chromatogr B. 2019; 1109:1-9.

  30. Du Y#, Xu BJ#, Deng X, Wu XW, Li YJ, Wang SR, Wang YN, Ji S, Guo MZ, Yang DZ, Tang DQ*. Predictive metabolic signatures for the occurrence and development of diabetic nephropathy and the intervention of Ginkgo biloba leaves extract based on gas or liquid chromatography with mass spectrometry. J Pharm Biomed Anal. 2019, 166:30-39.

  31. Asenso J#, Wang L#, Du Y, Liu QH, Xu BJ, Guo MZ, Tang DQ*. Advances in detection and quantification of methylcytosine and its derivatives. J Sep Sci. 2019; 42(5):1105-1116.

  32. Guo M, Liu D, Sha Q, Geng H, Liang J*, Tang D*. Succinic acid enhanced quantitative determination of blood modified nucleosides in the development of diabetic nephropathy based on hydrophilic interaction liquid chromatography mass spectrometry. J Pharm Biomed Anal. 2019; 164:309-316.

  33. Wu J, Li N, Yao Y, Tang D*, Yang D, Ong'achwa Machuki J, Li J, Yu Y, Gao F*. DNA-Stabilized Silver Nanoclusters for Label-Free Fluorescence Imaging of Cell Surface Glycans and Fluorescence Guided Photothermal Therapy. Anal Chem. 2018; 90(24):14368-14375.

  34. Yu Y, Yang Y, Wang F, Ding J, Meng S, Li C, Tang D*, Yin X**. Functional and biocompatible polymeric ionic liquid (PIL) - Decorated immunomagnetic nanospheres for the efficient capture of rare number CTCs. Anal Chim Acta. 2018; 1044:162-173.

  35. Ji S, Wang YJ, Su ZY, He DD, Du Y, Guo MZ, Yang DZ, Tang DQ*. Ionic liquids-ultrasound based efficient extraction of flavonoid glycosides and triterpenoid saponins from licorice. RSC Adv. 2018; 8(25): 13989-13996.

  36. Ji S, Liu ZZ, Wu J, Du Y, Su ZY, Wang TY, Han J, Yang DZ, Guo MZ, Tang DQ*. Chemical profiling and comparison of Sangju Ganmao tablet and its component herbs using two-dimensional liquid chromatography to explore compatibility mechanism of herbs. Front Pharmacol. 2018; 9:1167.

  37. Gao F, Yao Y , Wu J , Cui L , Zhang Y , Geng D , Tang D*, Yu Y . A robust fluorescent probe for detection of telomerase activity in vitro and imaging in living cells via telomerase-triggering primer extension to desorb DNA from graphene oxide. Analyst. 2018; 143(15):3651-3660.

  38. Gao FL, Wu J, Yao Y, Zhang Y, Liao XJ, Geng DQ, Tang DQ*. Proximity hybridization triggered strand displacement and DNAzyme assisted strand recycling for ATP fluorescence detection in vitro and imaging in living cells. RSC Adv. 2018; 8(49):28161-28171.

  39. Guo MZ, Zhang LY, Du Y, Du WC, Liu DT, Guo C, Pan YJ, Tang DQ*. Enrichment and quantitative determination of 5-(hydroxymethyl)-2'-deoxycytidine, 5-(formyl)-2'-deoxycytidine, and 5-(carboxyl)-2'-deoxycytidine in human urine of breast cancer by magnetic high-cross-linked microporous polymers based on poly-ionic liquid. Anal Chem. 2018; 90(6):3906-3913.

  40. Qiu J, Gong Q, Gao J, Chen W, Zhang Y, Gu X, Tang D*. Design, synthesis and evaluation of novel phenyl propionamide derivatives as non-nucleoside hepatitis B virus inhibitors. Eur J Med Chem. 2018; 144:424-434.


 

指导研究生情况(近五年)

近5年累计指导全日制研究生42人，其中毕业32人，在读10人。

 

主讲课程（近五年）

 近5年，主讲的研究生课程有：药学概论、药物色谱分析、中药分析选论、天然产物分离技术等

 

知识产权（近五年）

[1] 一种从厚朴中提取、分离纯化和厚朴酚及厚朴酚的方法。汤道权、孙世安、纪海侠、杨方秀、董露露、栗政。专利号：ZL201510448102.4
[2] 一种治疗心脑血管疾病的中药复方及其制备方法。汤道权、江相兰、郑笑笑。专利号：ZL201210564138.5

 

著作教材（近五年）

 1. 《药物分析》，编委，2016年，科学出版社。

2. 《药物分析》，编委，2017年，高等医药出版社。

 

发表论文(近五年)
科研项目(近五年)
科研专利(近五年)
获奖成果
教材专著

研究方向

体内药物分析