岳明辉,教授,硕士生导师。2013年毕业于中国科学院遗传与发育生物学研究所,随后在美国辛辛那提儿童医院从事博士后研究,并于2021年在宾夕法尼亚大学担任副研究员。2021年底入职徐州医科大学,2022年入选“江苏省双创博士”。近年来共发表SCI论文十篇,累计影响因子70分。目前主要研究方向包括:(1)哺乳动物胚胎颌面部发育的分子调控机制;(2)牙周炎发生过程中基因表达变化。
发表文章
Yue, M., Lan, Y., Liu, H., Wu, Z., Imamura, T., Jiang, R. (2021) Tissue-specific analysis of Fgf18 gene function in palate development. Dev Dyn
Yue, M. and Ogawa, Y. (2018) CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation. Nucleic Acids Res
Wang, Y., Li, Y., Yue, M., Wang, J., Kumar, S., Wechsler-Reya, R., Zhang, Z., Ogawa, Y., Kellis, M., Duester, G., Zhao, J. (2018) N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci
Yue, M., Ogawa, A., Yamada, N., Richard J.L.C., Barski, A., Ogawa, Y. (2017). Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression. PLoS Genet
Yue, M., Richard, J.L.C., and Ogawa, Y. (2016). Dynamic interplay and function of multiple noncoding genes governing X chromosome inactivation. Biochim Biophys Acta
Li, Q., Zhao, Y., Yue, M., Xue, Y., and Bao, S. (2016). The Protein Arginine Methylase 5 (PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage. J Genet Genomics
Yamada, N., Hasegawa, Y., Yue, M., Hamada, T., Nakagawa, S., and Ogawa, Y. (2015). Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. PLoS Genet
Yue, M.*, Charles Richard, J.L.*, Yamada, N., Ogawa, A., and Ogawa, Y. (2014). Quick Fluorescent in situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation. J Vis Exp
Yue, M.*, Li, Q.*, Zhang, Y., Zhao, Y., Zhang, Z., and Bao, S. (2013). Histone H4R3 Methylation Catalyzed by SKB1/PRMT5 Is Required for Maintaining Shoot Apical Meristem. PLoS One
Zhang, Z., Zhang, S., Zhang, Y., Wang, X., Li, D., Li, Q., Yue, M., Li, Q., Zhang, Y.-e, Xu, Y., Xue, Y., Chong, K., Bao, S. (2011). Arabidopsis Floral Initiator SKB1 Confers High Salt Tolerance by Regulating Transcription and Pre-mRNA Splicing through Altering Histone H4R3 and Small Nuclear Ribonucleoprotein LSM4 Methylation. Plant Cell
科研项目
江苏省卫健委,医学科研项目,下颌发育中 Msx1/2 通过 Wnt 信号调控麦克尔软骨 发育的分子机制,2025.01-2027.12.31,3万元,在研,主持
徐州市科学技术局, 徐州市科技计划项目, Msx1/2调控下颌发育的分子机制研究, 2023-09 至 2025-08, 10万元, 在研, 主持
徐州医科大学, 优秀人才启动基金, 下颌发育中Msx1/2的作用和机制, 2022-02 至2027-02, 70万元, 在研, 主持
徐州市卫健委,医学科技创新项目,磷酸酶PP2A激活剂FTY720治疗颌面部神经纤维瘤克服MEKi治疗 局限性的药物应用性研究,2025.01-2.26.12,10万元,在研,参与